Anthracycline-induced cardiac injuries and the effect of placenta cryoextract on the myocardium in doxorubicin cardiomyopathy

Background. Doxorubicin is the most widely used drug among anthracyclines. However, despite its clinical effectiveness, cardiotoxic effect observed in approximately 25,0% of patients, thus limiting use. Although significant success understanding individual pathogenetic elements this has been achieved, cancer patients who have doxorubicin-induced cardiac complications are currently treated mostly with drugs for insufficiency because there no specific treatment anthracycline cardiomyopathy.
 Purpose – to characterize placenta cryoextract on course doxorubicin myocardial injury model chronic cardiomyopathy compared reference vinboron according data biochemical analyses heart tissues.
 Materials and methods. Chronic was modeled by means injection hydrochloride at rate 5 mg/kg body weight once a week 4 weeks (on days 7, 14, 21, 28). The injected 1, 28. animals were withdrawn from experiment day 35. content adenylic nucleotides, glycogen, pyruvate, lactate, reactants thiobarbituric acid studied homogenates Results discussion. development accompanied impaired energy metabolism myocardium animals, as indicated statistically decrease adenosine triphosphoric (ATP) (p < 0,01) tissues 42,4% an increase diphosphoric (ADP) (р 0,05) monosphoric (AMP) 0,001) 45,4% 2,2 times respectively relative parameters intact rats. disbalance (p< acid. use leads nullifying deficit level ATP setting increased significantly 72,7%. In addition, cryoextract, «lactate/pyruvate» ratio decreased 51,9% which did not receive glycogen 2 rats treatment, but 38,9%.
 Conclusions. Placenta shows cardioprotective activity, meant be when you’re highlighting similarities, while supposed focusing differences vinboron, cardiomyopathy. One mechanisms mentioned activity ability produce energystabilizing cardiomyocytes, also antioxidative activity.